منابع مشابه
The exonuclease Trex1 restrains macrophage proinflammatory activation.
The three-prime repair exonuclease 1 (TREX1) is the most abundant exonuclease in mammalian cells. Mutations in Trex1 gene are being linked to the development of Aicardi-Goutières syndrome, an inflammatory disease of the brain, and systemic lupus erythematosus. In clinical cases and in a Trex1-deficient murine model, chronic production of type I IFN plays a pathogenic role. In this study, we dem...
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Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12-18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosol...
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If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity.
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Chloroviruses are large double-stranded DNA (dsDNA) viruses that infect certain isolates of chlorella-like green algae. They contain up to approximately 400 protein-encoding genes and 16 transfer RNA (tRNA) genes. This review summarizes the unexpected finding that many of the chlorovirus genes encode proteins involved in manipulating carbohydrates. These include enzymes involved in making extra...
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Hey Alice, I am a 19-year-old male and I am on the worst end of sugar intake. On normal days, I have found myself to consume upwards of 500 grams of sugar, and I have no idea how much I eat on special occasions where candy and other sweets are bountiful. I am a lanky kid with a family history of excessively high metabolisms. When I reach for a snack, I grab an entire box of cookies ? mostly van...
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ژورنال
عنوان ژورنال: Immunity
سال: 2015
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2015.08.026